Pharmacological evaluation of bee venom and melittin
نویسندگان
چکیده
منابع مشابه
Antimicrobial Activity of Bee Venom and Melittin against Borrelia burgdorferi
Lyme disease is a tick-borne, multi-systemic disease, caused by the bacterium Borrelia burgdorferi. Though antibiotics are used as a primary treatment, relapse often occurs after the discontinuation of antimicrobial agents. The reason for relapse remains unknown, however previous studies suggest the possible presence of antibiotic resistant Borrelia round bodies, persisters and attached biofilm...
متن کاملPossible mechanisms of action of cobra snake venom cardiotoxins and bee venom melittin.
Cobra snake venom cardiotoxins and bee venom melittin share a number of pharmacological properties in intact tissues including hemolysis, cytolysis, contractures of muscle, membrane depolarization and activation of tissue phospholipase C and, to a far lesser extent, an arachidonic acid-associated phospholipase A2. The toxins have also been demonstrated to open the Ca2+ release channel (ryanodin...
متن کاملisolating melittin from bee venom and evaluating its effect on proliferation of gastric cancer cells
background and purpose: gastric cancer (gc) is one of the most common cancers worldwide and in iran. as conventional therapies such as surgery and chemotherapy are invasive with adverse effects, current studies are important as they are conducted to find natural compounds with few adverse effects. in this study, melittin with 26 amino acids was isolated and purified from bee venom and its effec...
متن کاملQuantification of Melittin in Iranian Honey Bee (Apis mellifera meda) Venom by Liquid Chromatography-electrospray Ionization-ion Trap Tandem Mass Spectrometry (LC-ESI-IT-MS/MS)
The current research aimed to quantify melittin (MEL) in Iranian honey bee (Apis mellifera meda) venom. To this end, a liquid chromatography-electrospray ionization-ion trap tandem mass spectrometry (LC-ESI-IT-MS/MS) approach was employed. Melittin is the main toxic peptide of honey bee venom with various biological and pharmacological activities. It was extracted with...
متن کاملAnti-Inflammatory Applications of Melittin, a Major Component of Bee Venom: Detailed Mechanism of Action and Adverse Effects.
Inflammation is a pervasive phenomenon triggered by the innate and adaptive immune systems to maintain homeostasis. The phenomenon normally leads to recovery from infection and healing, but when not properly phased, inflammation may cause immune disorders. Bee venom is a toxin that bees use for their protection from enemies. However, for centuries it has been used in the Orient as an anti-infla...
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ژورنال
عنوان ژورنال: Revista Brasileira de Farmacognosia
سال: 2014
ISSN: 0102-695X
DOI: 10.1590/0102-695x20142413365